There exists a release of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors from the dorsal horn to minimize afferent discomfort transmission and deliver analgesia. Hence, medicine like clonidine that goal alpha-two receptors can impact the transmission of discomfort. Applies to clonidine: oral tablet, oral tablet https://single-bookmark.com/story19775668/the-2-minute-rule-for-onolidine