DNA ligases seal five′-PO4 and three′-OH polynucleotide ends via a few nucleotidyl transfer actions involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are vital guardians of genomic integrity, and ligase dysfunction underlies human genetic disorder syndromes. Crystal constructions of DNA ligases sure to nucleotide and nucleic acid substrates have illuminated https://richardq011ysl6.blogdiloz.com/profile