Sedative medicines such as benzodiazepines or connected medicines: The concomitant utilization of opioids with sedative medicines like benzodiazepines or relevant medicines increases the hazard of sedation, respiratory despair, coma and Dying due to additive CNS depressant impact. The dose and duration of concomitant use need to be confined (see part https://leopoldoh044zis1.wiki-cms.com/user